Clostridium difficile: Investigating Transmission Patterns Between Symptomatic and Asymptomatic Patients Using Whole Genome Sequencing
نویسندگان
چکیده
منابع مشابه
Asymptomatic Clostridium difficile Colonisation and Onward Transmission
INTRODUCTION Combined genotyping/whole genome sequencing and epidemiological data suggest that in endemic settings only a minority of Clostridium difficile infection, CDI, is acquired from other cases. Asymptomatic patients are a potential source for many unexplained cases. METHODS We prospectively screened a cohort of medical inpatients in a UK teaching hospital for asymptomatic C. difficile...
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Farm animals are a potential reservoir for human Clostridium difficile infection (CDI), particularly PCR ribotype 078 which is frequently found in animals and humans. Here, whole genome single-nucleotide polymorphism (SNP) analysis was used to study the evolutionary relatedness of C. difficile 078 isolated from humans and animals on Dutch pig farms. All sequenced genomes were surveyed for poten...
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BACKGROUND Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals. METHODS Serial isolates from two scenarios were whole genome sequenced. Firstly, 62 isolates from 29 timepoints from three in vitro gut models, ino...
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No study to date has compared multilocus variable-number tandem-repeat analysis (MLVA) and whole-genome sequencing (WGS) in an investigation of the transmission of Clostridium difficile infection. Isolates from 61 adults with ongoing and/or recurrent C. difficile infections and 17 asymptomatic carriage episodes in children (201 samples), as well as from 61 suspected outbreaks affecting 2 to 41 ...
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Determining the source of an infection can be difficult, but it is important for guiding interventions to interrupt outbreaks and prevent infections. Although many pathogens spread by person-to-person transmission, infections can also be acquired from food, animal, insect, or environmental sources. A publication by Eyre et al. in the New England Journal of Medicine sheds light on the source of ...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017